CAS號	93839-89-5	產(chǎn)地	國產(chǎn)
規(guī)格	5mg	級別	化工級
證書	ISO系列證書

ATPγS四鋰鹽 (Synonyms: Adenosine-5'-O-3-thiotriphosphate (tetralithium salt); Adenosine 5'-[γ-thio]triphosphate tetralithium salt)

ATPγS (tetralithium salt) 是真核生物翻譯起始因子 eIF4A 的核苷酸水解和RNA解鏈活性的底物。

生物活性

ATPγS (tetralithium salt) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A^[1].

體外研究(In Vitro)

ATPγS (tetralithium salt) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase^[1].
ATPγS (50-100 μM final blood concentration) attenuates inflammatory response with decreased accumulation of cells (48%, P < 0.01) and proteins (57%, P < 0.01) in bronchoalveolar lavage and reduces neutrophil infiltration and extravasation of Evans blue albumin dye into lung tissue^[3].

體內(nèi)研究(In Vivo)

ATPγS (tetralithium salt, 50 μM final, intravenous) demonstrates preserved lung parenchymal architecture^[3].
ATPγS results in a dose-dependent effect on EBA extravasation in LPS-treated mice^[3].

分子量：546.98

Formula：C₁₀H₁₂Li₄N₅O₁₂P₃S

CAS 號：93839-89-5

運輸條件：Room temperature in continental US; may vary elsewhere.

儲存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

參考文獻

[1]. Matthew L Peck, et al. Adenosine 5'-O-(3-thio)triphosphate (ATPgammaS) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. RNA. 2003 Oct;9(10):1180-7.
[2]. Z Y Wang, et al. Mg2+ and ATP or adenosine 5'-[gamma-thio]-triphosphate (ATP gamma S) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase. Biochim Biophys Acta. 1993 Sep 3;1202(1):47-55.
[3]. Irina A Kolosova, et al. Protective effect of purinergic agonist ATPgammaS against acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294(2):L319-24.

注：產(chǎn)品僅用于科研